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Acute Liver Failure and Myelosuppression due to Parvovirus B19 Infection: A Case Report

Jian Qi Lian1, Ye Zhang1, Li Liu1

  • 1Center of Infectious Diseases, Department of Hemotology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi province, China.

Gastroenterology Research
|December 14, 2016
PubMed

Insights

Parvovirus B19 infection can cause liver failure and bone marrow suppression in adults, though rare. Prompt testing for B19 virus antibodies is recommended for unexplained liver and blood cell issues.

Area of Science:

  • Virology
  • Hepatology
  • Hematology

Background:

  • Parvovirus B19 is linked to erythema infectiosum, arthropathy, and aplastic crisis.
  • Hepatopathy and myelosuppression are uncommon presentations of parvovirus B19 in adults.

Observation:

  • A rare case of adult parvovirus B19 infection presenting with acute liver failure and myelosuppression is detailed.
  • The patient received gamma globulin therapy.

Findings:

  • Treatment with gamma globulin led to improvements in liver function and bone marrow parameters.
  • This case highlights parvovirus B19 as a potential cause of acute liver injury and bone marrow suppression.

Implications:

  • Consider parvovirus B19 infection in adults with unexplained acute liver injury and/or myelosuppression.
  • Routine testing for B19 virus antibodies is advised for patients with these conditions.
Keywords:
Acute Liver FailureMyelosuppressionParvovirus B19

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