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Updated: Mar 10, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Relatively Long Survival in Hepatocellular Carcinoma Presenting With Carcinoid Syndrome
Sylvester Chuks Nwokediuko1, Ijoma Uchenna1, Ofoegbu Esther1
1Departments of Medicine, University of Nigeria Teaching Hospital Ituku/Ozall, Enugu, Nigeria.
Abstract:
Hepatocelluar carcinoma is one of the commonest cancers in Nigeria. Some patients may manifest a variety of paraneoplastic syndromes. Carcinoid syndrome is an extremely rare presentation of hepatocellular carcinoma. A 57-year old man presented with recurrent facial flushing and diarrhea, tricuspid regurgitation, and very high level of urinary hydroxyindoleacetic acid (HIAA) as the first manifestation of a multicentric hepatic lesion which proved histologically to be hepatocellular carcinoma. The lesions also exhibited arterial hypervascularization on contrast enhanced computerized tomography. The patient is still alive after 6 years of symptoms.

