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Updated: Mar 10, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
Complications From Left Atrial Appendage Exclusion Devices
Laura Perrotta1, Stefano Bordignon2, Daniela Dugo2
1Cardioangiologisches Centrum Bethanien - Markus Krankenhaus, Wilhelm Epstein Str. 4, 60431 Frankfurt am Main, Germany; University of Florence, Florence, Italy.
Insights
Atrial fibrillation increases stroke risk, prompting oral anticoagulation use. Left atrial appendage closure devices offer an alternative to reduce stroke risk, with this review focusing on procedural complications.
Area of Science:
- Cardiology
- Medical Devices
- Thrombosis
Background:
- Atrial fibrillation (AF) is a common arrhythmia and a significant risk factor for stroke.
- Oral anticoagulation (OAC) with Vitamin K antagonists (VKA) is standard for preventing thromboembolic events in AF.
- Long-term OAC therapy faces challenges due to bleeding risks and poor patient compliance.
Approach:
- This review examines current left atrial appendage (LAA) closure devices.
- Emphasis is placed on devices designed to prevent thrombi formation in the LAA.
- The discussion includes an in-depth analysis of complications associated with LAA closure procedures.
Key Points:
- The left atrial appendage is a primary source of cardiac thrombi in AF patients.
- LAA closure devices provide a potential alternative to systemic anticoagulation.
- Understanding procedural complications is crucial for patient safety and device selection.
Conclusions:
- LAA closure represents a promising strategy for stroke prevention in AF.
- Careful patient selection and procedural technique are vital to minimize complications.
- Further research is needed to optimize LAA closure device safety and efficacy.
Abstract:
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and has been identified as an independent risk factor for stroke. Prevention of thromboembolic events has been based on oral anticoagulation (OAC) using Vitamin K antagonists (VKA). However, long-term OAC medication is limited by an increased bleeding risk and a low patient compliance. Relying on the observation that the majority of cardiac thrombi originate from the left atrial appendage (LAA) different devices aiming for LAA closure have been proposed. This review will discuss contemporary LAA closure devices with special emphasis on procedure related complications.
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