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Updated: Mar 10, 2026

Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma
Se Won Kim1, Seung-Eun Lee2, Young Lyun Oh3
1Division of Endocrinology, Department of Internal Medicine, Sahmyook Medical Center, Seoul, Republic of Korea.
Abstract:
Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical carcinoma in a 39-year-old male with recurrent hypoglycemia. The patient's serum IGF-II/IGF-I ratio had increased to 27.8. The serum level of the IGF-II/IGF-I ratio was normalized after removal of the tumor, and the hypoglycemic attacks no longer occurred after the operation.
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