Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

9.2K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
9.2K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

578
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
578
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

7.3K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.3K
Metastasis02:30

Metastasis

6.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.7K
The Tumor Microenvironment02:17

The Tumor Microenvironment

8.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.0K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

8.7K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D bioprinting in regenerative medicine: From skin to organ engineering.

Annales de chirurgie plastique et esthetique·2025
Same author

World vitiligo day: a model for grassroots medical activism and pharmaceutical innovation.

Frontiers in medicine·2025
Same author

Mapping the vitiligo patient journey: from awareness to treatment or coping strategies.

Frontiers in rehabilitation sciences·2025
Same author

Evaluating the suitability of granular anammox biomass for nitrogen removal from vegetable tannery wastewater.

Biodegradation·2023
Same author

JEADV - the birth.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

A new Italian chemical peel, based on <i>Oenanthe crocata</i> extract.

Journal of biological regulators and homeostatic agents·2021
Same journal

Journal of wound care·2026
Same journal

Journal of wound care·2026
Same journal

Journal of wound care·2026
Same journal

Journal of wound care·2026
Same journal

Journal of wound care·2026
Same journal

Journal of wound care·2026
See all related articles

Related Experiment Video

Updated: Mar 10, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

21.9K

Wound-healing problems associated with cancers.

T Lotti1, C Rodofili2, M Bend3

  • 1Department of Dermatology, University of Siena, Siena, Italy.

Journal of Wound Care
|December 14, 2016
PubMed
Summary
This summary is machine-generated.

This guide details factors linked to malignant tumors that negatively impact wound healing in cancer patients. Understanding these adverse effects is crucial for improving patient outcomes and recovery processes.

More Related Videos

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

14.4K
Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

10.0K

Related Experiment Videos

Last Updated: Mar 10, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

21.9K
Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

14.4K
Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

10.0K

Area of Science:

  • Oncology
  • Surgical Pathology
  • Wound Healing Research

Background:

  • Malignant tumors present unique challenges in patient care, particularly concerning surgical recovery.
  • Impaired wound healing is a significant complication in cancer patients, affecting treatment efficacy and quality of life.

Purpose of the Study:

  • To provide a comprehensive overview of factors associated with malignant tumors that adversely affect wound healing.
  • To serve as a clinical guide for healthcare professionals managing cancer patients with wound healing complications.

Main Methods:

  • Literature review and synthesis of current research on tumor-related wound healing impediments.
  • Analysis of clinical data and case studies focusing on oncological wound complications.

Main Results:

  • Identification of key tumor characteristics (e.g., tumor microenvironment, angiogenesis, invasiveness) influencing wound healing.
  • Correlation of specific cancer types and treatment modalities with delayed or non-healing wounds.

Conclusions:

  • Malignant tumors significantly complicate wound healing through various biological and clinical mechanisms.
  • Targeting tumor-specific factors offers potential therapeutic strategies to improve wound healing in cancer patients.