[Pharmacokinetic evaluations and analysis of aztreonam in children]

Aztreonam (AZT), monocyclic beta-lactam antimicrobial agent, was administered to 9 children at a dose level of 30 mg/kg through intravenous drip infusion for half-hour. Using serum levels of the drug obtained in blood samples, pharmacokinetic parameters were calculated and a simulation curve of serum levels was drawn automatically using a micro-computer. The mean values (n = 9) for elimination constant (Kel) and half-life (T 1/2) were 0.67 hr-1 and 1.08 hours, respectively. The mean apparent volume of distribution was 4.29 L, and serum clearance was 0.17 L/kg/hr. A basic analysis for the efficacy dose of AZT was performed using above mentioned parameters.