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[Experimental study on transferability to cerebrospinal fluid of cefodizime in combination with ampicillin]
K Okura1, T Haruta, Y Kobayashi
1Department of Pediatrics, Kobe City General Hospital.
Abstract:
A study was done on cefodizime (THR-221, CDZM) in combination with ampicillin (ABPC) for its transferability to cerebrospinal fluid (CSF) of rabbits with experimental meningitis caused by Staphylococcus aureus. Blood and CSF were collected at 15, 30, 45, 60, 90, 120 and 180 minutes after intravenous administration of CDZM at 100 mg/kg to 6 rabbits, ABPC at 100 mg/kg to 4 rabbits and simultaneous administration of both drugs at 100 mg/kg each to 5 rabbits. Drug concentrations were assayed with an high performance liquid chromatography method, and pharmacokinetic parameters were calculated. The comparison revealed no significant difference in concentrations achieved among different groups. Therefore, the mutual transferability of these drugs to CSF was not considered to interact adversely due to the simultaneous administration of both drugs. Accordingly, CDZM may be a candidate of chemotherapeutics in the therapy of purulent meningitis, and it is worthy of further investigations.
Insights
Cefodizime (CDZM) and ampicillin (ABPC) can be administered together for meningitis treatment. Simultaneous administration did not affect drug transfer to cerebrospinal fluid (CSF) in rabbits.
Area of Science:
- Pharmacology
- Infectious Diseases
- Neuroscience
Context:
- Bacterial meningitis, particularly Staphylococcus aureus meningitis, poses a significant therapeutic challenge.
- Cerebrospinal fluid (CSF) penetration is crucial for effective antibiotic treatment of meningitis.
- Assessing drug interactions and transferability is vital for optimizing combination therapies.
Purpose:
- To evaluate the pharmacokinetics and transferability of cefodizime (CDZM) and ampicillin (ABPC) into the cerebrospinal fluid (CSF) of rabbits with experimental Staphylococcus aureus meningitis.
- To determine if simultaneous administration of CDZM and ABPC affects their individual or combined transfer into the CSF.
- To assess the potential of CDZM as a chemotherapeutic agent for purulent meningitis.
Summary:
- This study investigated the transfer of cefodizime (CDZM) and ampicillin (ABPC) into rabbit CSF during experimental meningitis.
- Pharmacokinetic parameters were analyzed after individual and combined intravenous administration of CDZM and ABPC.
- Results showed no significant adverse interaction affecting drug concentrations in CSF upon simultaneous administration.
Impact:
- The findings suggest that cefodizime (CDZM) can be a potential candidate for treating purulent meningitis when used in combination with ampicillin (ABPC).
- This study supports the potential for combined CDZM and ABPC therapy without compromising CSF drug levels.
- Further research is warranted to explore the clinical efficacy of this combination therapy for bacterial meningitis.
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