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Updated: Mar 10, 2026
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
New aspects of postmenopausal osteoporosis treatment with micronized estradiol and progesterone
Jarosław von Mach-Szczypiński1, Stanisław Stanosz, Jakub Kościuszkiewicz
1Department of Menopause and Andropause, Pomeranian Medical University, Szczecin, Poland. magnum@pum.edu.pl.
Objectives:
The aim of the study was to assess the effectiveness of postmenopausal osteoporosis treatment with natural sex hormones.
Material And Methods:
The single-blind study included 210 women, randomly allocated to three different groups, with various methods of treatment: Group I (70 controls) received transcutaneous placebo for the course of one year, Group II (70 females, aged 52.2 ± 3.1 years) used oral hormone supplementary therapy (HST), and Group III (70 females, aged 51.9 ± 3.5 years) received transcutaneous modified hormone replacement therapy (MHRT), supplemented with intravaginal lutein, dietary minerals, and 1000 IU of vitamin D3/day.
Results:
No increase in bone mineral density was observed in the control group. However, mineral density of the vertebral bodies was significantly higher after 3 and 5 years in the HST group (p < 0.05), and after 1 year in the MHRT group (p < 0.01). This increase was even more significant (p < 0.001) after 3 and 5 years in the MHRT group.
Conclusions:
Transcutaneous hormone therapy with micronized estradiol and progesterone is the treatment of choice in postmenopausal osteoporosis, as evidenced by bone mineral density and biochemical markers.
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