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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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Drug-Induced Liver Injury

Leslie A Hamilton1, Angela Collins-Yoder1, Rachel E Collins1

  • 1Leslie Hamilton is Associate Professor of Clinical Pharmacy, University of Tennessee Health Science Center College of Pharmacy, Knoxville, Tennessee. Angela Collins-Yoder is Clinical Professor, Capstone College of Nursing, and Critical Care Nurse Specialist, Sacred Heart Pensacola Hospital, 8370 Foxtail Loop, Pensacola, FL 32526 (acollins-yoder@ua.edu). Rachel E. Collins is a PharmD candidate, Auburn University Harrison School of Pharmacy, Auburn, Alabama.

AACN Advanced Critical Care
|December 14, 2016
PubMed
Summary

Drug-induced liver injury (DILI) has both predictable (intrinsic) and unpredictable (idiosyncratic) causes from medications and supplements. Identifying patient risk factors and understanding DILI mechanisms are crucial for effective management and future research.

Keywords:
adverse drug reactionsclinical practice guidelinesdrug-induced liver injuryherbal and dietary supplements

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