Clostridium difficile Infection and Fecal Microbiota Transplant

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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

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Alyssa Liubakka1, Byron P Vaughn1

  • 1Alyssa Liubakka is an Internal Medicine Resident, Department of Medicine, University of Minnesota, 420 Delaware Street SE, MMC 284, Minneapolis, MN 55455 (e-mail: liuba006@umn.edu). Byron P. Vaughn is an Assistant Professor of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, and part of the Microbiota Therapeutics Program, University of Minnesota, Minneapolis, Minnesota.

AACN Advanced Critical Care
|December 14, 2016
PubMed

Insights

Clostridium difficile infection (CDI) is a significant healthcare concern. Fecal microbiota transplant (FMT) shows high efficacy for recurrent CDI, offering a novel treatment option.

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Microbiology

Background:

  • Clostridium difficile infection (CDI) causes significant morbidity and mortality in hospitalized patients.
  • Up to 30% of patients experience recurrent CDI despite existing antimicrobial therapies.

Purpose of the Study:

  • To review the epidemiology, diagnosis, and treatment of CDI.
  • To evaluate the role of fecal microbiota transplant (FMT) for recurrent, severe, or refractory CDI.

Main Methods:

  • Literature review of CDI epidemiology, diagnosis, and treatment modalities.
  • Analysis of studies on fecal microbiota transplant efficacy for recurrent CDI.

Main Results:

  • Fecal microbiota transplant demonstrates nearly 90% efficacy in patients with multiple recurrent CDI.
  • FMT is a promising approach for severe or refractory CDI cases.

Conclusions:

  • Fecal microbiota transplant is a highly effective treatment for recurrent Clostridium difficile infection.
  • FMT represents a significant advancement in managing complex CDI cases.
Keywords:
Clostridium difficile infectionfecal microbiota transplantfecal transplantrecurrent C difficile infection

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