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To PFKFB3 or Not to PFKFB3, That Is the Question
Cristina Branco1, Randall S Johnson2
1Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.
Abstract:
In this issue of Cancer Cell, Cantelmo et al. describe how reduction of PFKFB3 enzyme activity can promote vascular normalization. The authors show in turn how this affects vascular permeability and can ultimately improve the efficacy of chemotherapeutic agents.
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