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Updated: Mar 10, 2026
Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality
Published on: June 2, 2023
A highly sensitive fluorescent chemosensor for selective detection of zinc (II) ion based on the oxadiazole
Lu Lin1, Dan Wang1, Si-Hong Chen1
1College of Chemistry and Chemical Engineering, Hubei Collaborative Innovation Center for Rare Metal Chemistry, Hubei Key Laboratory of Pollutant Analysis and Reuse Technology, Hubei Normal University, Huangshi 435002, China.
Abstract:
A novel fluorescent chemosensor based on the oxadiazole, 2-(2-hydroxyphenyl)-5-(4-methoxyphenyl)-1,3,4-oxadiazole, was designed and synthesized. The interaction of the oxadiazole with different metal ions had been investigated through UV-vis absorption and fluorescence spectra in 9:1 (v/v) ethanol-water (pH=7.0) solution. The oxadiazole showed a pronounced fluorescence enhancement at 430nm upon addition of Zn2+ in aqueous solution, whereas it had no apparent interference from other metal ions. The results indicated that the oxadiazole possessed high selectivity and sensitivity to Zn2+ ion. The stoichiometric ratio between the oxadiazole and Zn2+ ion was calculated to be 2:1 by Job plot experiment, meanwhile their binding modes was confirmed by 1H NMR and mass spectrometry. Their association constant was determined to be 1.95×105M-1 and the detection limit for Zn2+ ion was 6.14×10-7mol/L.
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