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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration
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Combining Gene and Stem Cell Therapy for Peripheral Nerve Tissue Engineering.

Francesca Busuttil1, Ahad A Rahim1, James B Phillips2

  • 11 Department of Pharmacology, UCL School of Pharmacy, University College London , London, United Kingdom .

Stem Cells and Development
|December 15, 2016
PubMed
Summary
This summary is machine-generated.

Peripheral nerve injury recovery is limited. Therapeutic cells in engineered devices may enhance nerve regeneration by maintaining Schwann cell proregenerative phenotypes for better functional outcomes.

Keywords:
gene therapyperipheral nerve regenerationtissue engineering

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Biotechnology

Background:

  • Peripheral nerve injury leads to insufficient functional recovery, a major clinical issue.
  • Schwann cells are crucial for nerve regeneration, adopting a proregenerative phenotype post-injury.
  • This proregenerative phenotype duration is often insufficient for complete functional recovery.

Purpose of the Study:

  • To review preclinical evidence on enhancing nerve regeneration.
  • To explore the potential of tissue-engineered nerve repair devices.
  • To summarize gene and cell therapy strategies for peripheral nerve repair.

Main Methods:

  • Literature review of preclinical studies.
  • Analysis of Schwann cell behavior and phenotype maintenance.
  • Evaluation of tissue engineering and combined gene/cell therapy approaches.

Main Results:

  • Schwann cells' proregenerative phenotype is critical but transient.
  • Tissue-engineered devices with therapeutic cells show promise.
  • Gene and cell therapy offer a synergistic approach to nerve regeneration.

Conclusions:

  • Maintaining Schwann cell proregenerative phenotype is key for nerve repair.
  • Tissue engineering combined with gene and cell therapy holds translational potential.
  • Further preclinical research is needed to advance nerve regeneration therapies.