Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Monocytes and focal glomerulosclerosis.

A B Magil¹, A H Cohen

¹Department of Pathology, University of British Columbia, Vancouver, Canada.

Laboratory Investigation; a Journal of Technical Methods and Pathology

|October 1, 1989

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Increased susceptibility to hypertensive renal disease in streptozotocin-treated diabetic rats is not modulated by salt intake.

Diabetologia·2012

Same author

Spikes alone do not behavior make: why neuroscience needs biomechanics.

Current opinion in neurobiology·2011

Same author

Developmental changes in the ultrastructure of the lamprey lateral line nerve during metamorphosis.

Journal of morphology·2009

Same author

Enzyme replacement therapy stabilizes obstructive pulmonary Fabry disease associated with respiratory globotriaosylceramide storage.

Journal of inherited metabolic disease·2008

Same author

Metamorphosis-related changes in the lateral line system of lampreys, Petromyzon marinus.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2008

Same author

Larval lampreys possess a functional lateral line system.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2006

Monocytes and foam cells are significantly present in focal glomerulosclerosis (FGS) lesions, suggesting their role in disease development. This finding offers new insights into FGS pathogenesis.

Area of Science:

Nephrology
Immunology
Pathology

Background:

Focal glomerulosclerosis (FGS) shares similarities with atherosclerosis.
Monocytes and their derivatives are implicated in atherosclerosis pathogenesis.

Purpose of the Study:

To investigate the potential role of monocytes and their derivatives in the development of focal glomerulosclerosis (FGS).

Main Methods:

Combined histochemical (nonspecific esterase, lysozyme staining) and ultrastructural (electron microscopy) analysis of 13 FGS biopsies.
Quantification of monocytes and foam cells in glomeruli with and without sclerotic lesions.

Main Results:

Monocytes and/or foam cells were found in 72% of glomeruli with FGS lesions versus 7% without (p<0.0001).

Related Experiment Videos

Foam cells predominated over monocytes in sclerotic glomeruli.

Early FGS lesions showed intracapillary cells with monocytic features, progressing to more frequent foam cells.

Conclusions:

Monocytes and their derivatives, particularly foam cells, are significantly involved in the pathogenesis of focal glomerulosclerosis.
These findings support the analogy between FGS and atherosclerosis regarding cellular mechanisms.