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Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
Published on: April 24, 2016
Recurrent malignant salivary gland neoplasms
M A Rodriguez-Bigas1, K Sako, M S Razack
1Department of Head and Neck Surgery, Roswell Park Memorial Institute, Buffalo, New York 14263.
Journal of Surgical Oncology
|October 1, 1989
Summary
Retreatment of recurrent salivary gland tumors has a poor prognosis. This study found limited success in achieving disease-free survival through aggressive retreatment methods for these rare cancers.
Area of Science:
- Oncology
- Head and Neck Surgery
- Cancer Research
Background:
- Recurrent salivary gland malignancies pose significant therapeutic challenges.
- Treatment for recurrent salivary gland tumors is often palliative due to poor prognosis.
Purpose of the Study:
- To evaluate the efficacy of aggressive retreatment strategies for recurrent and metastatic salivary gland tumors.
- To assess the outcomes of curative-intent interventions for patients with previously treated salivary gland malignancies.
Main Methods:
- Retrospective analysis of 352 patients with major and minor salivary gland tumors from 1960-1984.
- Focus on 99 patients with recurrent/metastatic tumors initially treated elsewhere.
- Evaluation of curative-intent treatments including surgery, radiation, and chemotherapy.
Main Results:
- Five-year survival with no evidence of disease was achieved in 5 out of 33 patients undergoing curative-intent retreatment.
- Successful cases included specific types of adenoid cystic carcinoma, mucoepidermoid carcinoma, and sebaceous cell carcinoma.
- The overall yield of retreatment for loco-regional recurrence was relatively poor.
Conclusions:
- Aggressive retreatment for recurrent salivary gland tumors yields limited success.
- Curative-intent interventions may offer a chance of long-term survival in select cases.
- Further research is needed to optimize treatment for these challenging malignancies.
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