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Genes associated with persistent lumbar radicular pain; a systematic review
Siri Bjorland1,2, Aurora Moen3,4, Elina Schistad3
1Faculty of Medicine, University of Oslo, 1072 Blindern, Oslo, 0316, Norway. sibjorl@online.no.
BMC Musculoskeletal Disorders
|December 15, 2016
Summary
Certain genetic factors and biomarkers may predict slow recovery in lumbar radicular pain (LRP). Further research is needed to confirm these findings and standardize nomenclature for genetic variants and biomarkers.
Area of Science:
- Genetics
- Biomarkers
- Pain Medicine
Background:
- Lumbar radicular pain (LRP) is a common condition.
- Predicting pain recovery is crucial for patient management.
- Genetic factors and biomarkers may influence LRP outcomes.
Purpose of the Study:
- To review literature on genetic factors and biomarkers predicting pain recovery in LRP patients.
- To identify specific genetic variants and serum proteins associated with LRP recovery.
- To assess the current evidence for predictive factors in LRP.
Main Methods:
- Systematic literature search in Medline OVID, Embase, PsycInfo, and Web of Science (2004-2015).
- Inclusion of prospective studies on LRP patients examining genetic susceptibility and serum pain biomarkers.
- Data extraction and quality assessment by two independent reviewers.
Main Results:
- Fifteen studies met inclusion criteria from 880 initial citations.
- Five genetic variants (OPRM1, COMT, MMP1, IL1α, IL1RN) were linked to reduced LRP recovery.
- Three biomarkers (TNFα, IL6, IFNα) were associated with persistent LRP.
Conclusions:
- Genetic factors and biomarkers show potential in predicting slow recovery from LRP.
- Replication of findings is necessary due to the limited number of studies.
- Standardized nomenclature for genetic and biomarker research in LRP is required.
