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Published on: July 4, 2014
Magnetic Resonance Imaging to Visualize Disintegration of Oral Formulations
Louise Curley1, Jordan Hinton1, Cameron Marjoribanks2
1The University of Auckland, School of Pharmacy, Auckland 1142, New Zealand.
Abstract:
This article demonstrates that magnetic resonance imaging can visualize the disintegration of a variety of paracetamol containing oral formulations in an in vitro setting and in vivo in the human stomach. The different formulations had unique disintegration profiles which could be imaged both in vitro and in vivo. No special formulation approaches or other contrast agents were required. These data demonstrate the potential for further use of magnetic resonance imaging to investigate and understand the disintegration behavior of different formulation types in vivo, and could potentially be used as a teaching tool in pharmaceutical and medical curricula.
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