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Mitochondria and mitochondria-induced signalling molecules as longevity determinants
Giuseppina Rose1, Aurelia Santoro2, Stefano Salvioli2
1Department of Biology, Ecology and Earth Science, University of Calabria, Rende (CS), Italy.
Mechanisms of Ageing and Development
|December 15, 2016
Summary
Mitochondria and nucleus communication triggers a stress response that enhances cell survival and longevity. This review explores mitochondria
Area of Science:
- Cellular biology
- Mitochondrial function
- Aging research
Background:
- Mitochondria and nucleus crosstalk is vital for cellular stress response and survival.
- This response can extend lifespan in animal models but is less understood in humans.
Purpose of the Study:
- To review the role of mitochondria in longevity.
- To focus on mitochondria-mediated signaling and stress response.
- To propose potential benefits for human aging and longevity.
Main Methods:
- Literature review of existing studies on mitochondria, signaling, and aging.
- Analysis of data on mitochondria-nucleus communication and stress response pathways.
- Synthesis of findings to support the hypothesis on human longevity.
Main Results:
- Mitochondrial stress response strengthens cells and promotes survival.
- Signaling pathways involving mitochondria can impact distal tissues.
- Consistent lifespan extension observed in various animal models.
Conclusions:
- Mitochondria play a crucial role in cellular stress response and survival.
- Mitochondria-mediated signaling may offer benefits for human aging.
- Further research is needed to fully understand and harness this response for human longevity.
Keywords:
Human longevityMito-nuclear communicationMitochondriaMitochondrial epigeneticsMitochondrial uncouplingMitokinesUPR(mt)More Related Videos
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