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Related Experiment Video

Updated: Mar 10, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
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Development of a Microscopic Colitis Disease Activity Index: a prospective cohort study.

Thomas G Cotter1, Moritz Binder1, Edward V Loftus2

  • 1Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Gut
|December 15, 2016
PubMed
Summary

A new Microscopic Colitis Disease Activity Index (MCDAI) was developed to assess disease severity in microscopic colitis (MC). The MCDAI accurately predicts physician assessments and correlates with quality of life, aiding treatment comparisons.

Keywords:
CLINICAL TRIALSCOLLAGENOUS COLITISLYMPHOCYTIC COLITISMICROSCOPIC COLITIS

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Area of Science:

  • Gastroenterology
  • Clinical Medicine
  • Disease Assessment

Background:

  • Microscopic colitis (MC) is a frequent cause of chronic diarrhea.
  • Lack of validated instruments hinders MC treatment efficacy comparison.
  • Need for objective disease activity assessment in MC.

Purpose of the Study:

  • Identify clinical features predicting MC disease severity.
  • Develop and validate a Microscopic Colitis Disease Activity Index (MCDAI).

Main Methods:

  • Prospective survey of MC patients assessing GI symptoms and quality of life (IBDQ).
  • Physician global assessment (PGA) of disease severity.
  • Multiple linear regression to identify predictors of PGA.
  • Creation of MCDAI using a weighted formula of key symptoms.

Main Results:

  • 162 MC patients completed the study (median age 66, 74% female).
  • Key predictors of PGA included stool frequency/nocturnal stools, abdominal pain, weight loss, urgency, and incontinence.
  • The developed MCDAI strongly predicted PGA (R²=0.80).
  • A decrease in MCDAI correlated with improved quality of life (IBDQ).

Conclusions:

  • The MCDAI is a reliable tool for assessing MC disease activity.
  • MCDAI strongly predicts physician global assessment and correlates with quality of life.
  • Clinical features beyond diarrhea are crucial for evaluating MC severity.