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Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
Published on: January 8, 2014
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A novel method for fabricating engineered structures with branched micro-channel using hollow hydrogel fibers
Shuai Li1, Yuanyuan Liu, Yu Li1
1Rapid Manufacturing Engineering Center, Shanghai University , Shanghai 200444, People's Republic of China.
Biomicrofluidics
|December 15, 2016
Summary
This study presents a novel 3D bioprinting method for fabricating engineered structures with branched micro-channels (ESBM) essential for tissue vascularization. The technique rapidly produces functional hollow hydrogel fibers, demonstrating biocompatibility and potential for regenerative medicine.
Area of Science:
- Biomaterials Engineering
- Regenerative Medicine
- Tissue Engineering
Background:
- Vascularization is critical for tissue regeneration, supplying oxygen and nutrients.
- Fabricating engineered structures with branched micro-channels remains a significant technological challenge.
Purpose of the Study:
- To introduce and validate a novel method for fabricating engineered structures with branched micro-channels (ESBM).
- To assess the manufacturability, mechanical properties, and biocompatibility of the fabricated structures.
Main Methods:
- Utilized a 3D bioprinter with a triaxial nozzle to coaxially extrude sodium alginate and calcium chloride.
- Optimized material concentrations and cross-linking for rapid fabrication of hollow hydrogel fibers.
- Evaluated mechanical properties, perfusion capabilities, and fibroblast viability.
Main Results:
- Successfully fabricated ESBM using sodium alginate and calcium chloride hydrogel fibers.
- Demonstrated good perfusion of cell media through the branched channels.
- Confirmed high fibroblast viability, indicating non-cytotoxicity of the fabrication process.
Conclusions:
- Hollow hydrogel fibers fabricated via this 3D bioprinting method offer a promising approach for creating vascularized engineered tissues.
- The developed technique addresses the technological barrier in producing complex branched micro-channel structures for regenerative applications.
