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Related Experiment Video

Updated: Mar 10, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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[Transcorneal electrical stimulation in primary open angle glaucoma].

T Röck1, L Naycheva2, G Willmann1,3

  • 1Department für Augenheilkunde, Eberhard Karls Universität Tübingen, Tübingen, Deutschland.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|December 15, 2016
PubMed
Summary
This summary is machine-generated.

Transcorneal electrical stimulation (TES) showed no serious adverse events in primary open angle glaucoma (POAG) patients. Further research is needed before widespread clinical use of TES for POAG.

Keywords:
NeuroprotectionPrimary open angle glaucomaTranscorneal electrical stimulationVisual acuityVisual function

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Biomedical Engineering

Background:

  • Neurodegenerative ocular diseases, like primary open angle glaucoma (POAG), are a leading cause of vision loss.
  • Electrical stimulation has emerged as a potential therapeutic modality for these conditions.
  • Transcorneal electrical stimulation (TES) using DTL electrodes is being investigated for its efficacy and safety.

Purpose of the Study:

  • To evaluate the safety and efficacy of transcorneal electrical stimulation (TES) in patients with primary open angle glaucoma (POAG).
  • To assess adverse events and visual function parameters following TES treatment.

Main Methods:

  • 14 patients with POAG were randomized into three groups: sham (0%), 66% phosphene threshold, and 150% phosphene threshold.
  • Patients received TES for 30 minutes weekly for six weeks.
  • Outcomes included adverse events, intra-ocular pressure, and visual function tests.

Main Results:

  • TES was well-tolerated with no serious adverse events. One optic disc hemorrhage occurred in a sham-stimulated eye.
  • A statistically significant increase in intra-ocular pressure was observed in the 66% group compared to sham, but it was not clinically meaningful.
  • No significant differences in visual field tests or other objective/subjective visual function parameters were found between groups.

Conclusions:

  • Transcorneal electrical stimulation (TES) using DTL electrodes is safe for patients with primary open angle glaucoma (POAG).
  • Current evidence does not support a significant therapeutic benefit of TES for POAG.
  • TES should only be administered to POAG patients within study settings.