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Gait patterns associated with thyroid function: The Rotterdam Study.

Arjola Bano1,2,3, Layal Chaker1,2,3,4, Sirwan K L Darweesh3,4

  • 1Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.

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|December 15, 2016
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Summary
This summary is machine-generated.

Thyroid dysfunction, both low and high, impacts gait patterns. This population study found thyroid-stimulating hormone (TSH) levels are linked to gait alterations, affecting balance and walking speed.

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Area of Science:

  • Endocrinology
  • Gerontology
  • Biomedical Engineering

Background:

  • Gait is a crucial health indicator, with deterioration linked to disability and falls.
  • Thyroid dysfunction's role in gait decline is suggested but lacks population-based evidence.
  • Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) are key thyroid function markers.

Purpose of the Study:

  • To investigate the association between thyroid function (TSH and FT4) and gait patterns.
  • To explore how thyroid dysfunction influences various gait domains and velocity.
  • To examine these relationships in a large, population-based cohort without known thyroid disease or dementia.

Main Methods:

  • Utilized data from 2645 participants in the Rotterdam Study.
  • Assessed gait using an electronic walkway, measuring Global gait and specific domains.
  • Employed multivariable regression models to analyze TSH and FT4 associations with gait parameters.

Main Results:

  • An inverted U-shaped association was found between TSH levels and Global gait (p < 0.001).
  • TSH was linked to Base of Support (p=0.01), Tandem gait (p=0.002), and velocity (p=0.02) in inverted U-shaped patterns.
  • Both clinical and subclinical hypothyroidism showed worse Global gait compared to euthyroidism (p=0.004 and p=0.04, respectively).

Conclusions:

  • Both low and high thyroid function are associated with significant alterations in Global gait, Tandem gait, Base of Support, and velocity.
  • Thyroid function, particularly TSH levels, plays a role in maintaining normal gait patterns.
  • These findings highlight the importance of thyroid health for mobility and fall prevention.