Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teratogenicity01:07

Teratogenicity

4.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.4K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

38.2K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
38.2K
Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

3.6K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal exposure to biosolids reshapes chemical burden and steroidogenic pathways to promote adipogenic differentiation in a sheep model.

Environment international·2026
Same author

Living in a chemical cocktail: real-world mixture exposures and their impact on ovarian function.

The Journal of reproduction and development·2026
Same author

Early Pregnancy Targeted Exposome: Biological Response and Maternal BMI.

Toxics·2026
Same author

Microporous Immune-Isolating Capsule with Improved Diffusion for Restored Dynamic Bidirectional Hormone Signaling in a Murine Model of Premature Ovarian Insufficiency.

bioRxiv : the preprint server for biology·2026
Same author

Sex-specific multigenerational epigenetic responses to real-world chemical mixture exposure in an outbred sheep model.

bioRxiv : the preprint server for biology·2026
Same author

Role of antioxidant vitamins in mitigating the health risks from environmental toxicant exposures: a narrative review.

Journal of the Endocrine Society·2026

Related Experiment Video

Updated: Mar 10, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

12.0K

Gestational Hyperandrogenism in Developmental Programming.

Christopher Hakim1, Vasantha Padmanabhan2, Arpita K Vyas1,3

  • 1College of Human Medicine, Michigan State University, East Lansing, Michigan.

Endocrinology
|December 15, 2016
PubMed
Summary

Androgen excess, or hyperandrogenism, in women can stem from various conditions. This review examines gestational hyperandrogenism causes and its impact on fetal development.

More Related Videos

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
14:40

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

9.9K
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.6K

Related Experiment Videos

Last Updated: Mar 10, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
08:20

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Published on: October 2, 2018

12.0K
Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
14:40

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

9.9K
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.6K

Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Maternal-Fetal Medicine

Background:

  • Hyperandrogenism is a prevalent endocrine disorder in women of reproductive age.
  • Common causes include polycystic ovary syndrome, congenital adrenal hyperplasia (CAH), and adrenal tumors.
  • Pregnancy introduces specific causes like luteoma, placental aromatase deficiency, and fetal CAH.

Purpose of the Study:

  • To review the diverse phenotypes of hyperandrogenism during pregnancy.
  • To explore the origins and pathophysiology of gestational hyperandrogenism.
  • To analyze the effects of maternal hyperandrogenism on fetal development and offspring outcomes.

Main Methods:

  • Literature review of existing studies on hyperandrogenism in pregnancy.
  • Synthesis of information on etiological factors and clinical presentations.
  • Analysis of research on fetal and offspring consequences.

Main Results:

  • Identified multiple causes of hyperandrogenism specific to pregnancy.
  • Detailed the pathophysiological mechanisms underlying gestational hyperandrogenism.
  • Highlighted the potential impact on fetal development and long-term health.

Conclusions:

  • Gestational hyperandrogenism presents unique challenges and requires careful management.
  • Understanding the origins and effects is crucial for optimizing fetal and offspring health.
  • Further research is needed to fully elucidate long-term consequences.