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New evidence for oxetorone toxicity
Marie Deguigne1, Chloé Bruneau1, Ali Touré1
1a Centre Antipoison et Toxicovigilance, CHU Angers , Angers , France.
Clinical Toxicology (Philadelphia, Pa.)
|December 15, 2016
Summary
Oxetorone overdose can cause severe symptoms like coma and cardiac issues, with toxicity correlating to ingested dose. Delayed symptom onset and worsening were observed, suggesting membrane-stabilizing effects.
Area of Science:
- Toxicology
- Pharmacology
- Clinical Medicine
Background:
- Oxetorone is a serotonin antagonist used for migraines.
- Limited data exists on oxetorone's toxic properties.
- This study investigates the toxicological profile of oxetorone.
Purpose of the Study:
- To describe the toxicological profile of oxetorone.
- To correlate clinical and analytical findings with oxetorone exposure.
- To assess the relationship between ingested dose and toxicity severity.
Main Methods:
- Retrospective observational study of oxetorone exposures (2002-2016).
- Data from Angers Poison and Toxicovigilance Centre.
- Exclusion criteria included incomplete data, non-accountable oxetorone, co-ingestion, or negative plasma concentration.
Main Results:
- 43 cases included; 31 were suicide attempts.
- Ingested dose (60-3600 mg) correlated with severity (r=0.45, p=0.01).
- Moderate symptoms (PSS2) from >600 mg; severe symptoms (PSS3) from 1800 mg. Delayed worsening (10-48h) in 4 cases. Plasma concentration >0.3 mg/L associated with severe symptoms.
Conclusions:
- Clinical and paraclinical data suggest membrane-stabilizing properties of oxetorone.
- Risk of delayed symptom onset or secondary worsening exists.
- Importance of monitoring plasma oxetorone levels and delayed toxicity.
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