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Updated: Sep 16, 2026

Chromosomics: Detection of Numerical and Structural Alterations in All 24 Human Chromosomes Simultaneously Using a Novel OctoChrome FISH Assay
Published on: February 6, 2012
Localization of breakpoints in the karyotype of workers professionally exposed to benzene
M Sasiadek1, J Jagielski, R Smolik
1Department of Pathophysiology, Medical Academy of Wrocław, Poland.
Abstract:
Cytogenetic analysis was carried out on peripheral blood lymphocytes of 33 workers professionally exposed to benzene for 10-26 years. In the examined group structural chromosome aberrations were found in 147 metaphases (4.7%). Statistical analysis has shown that the distribution of breakpoints was not random. Chromosomes 2, 4 and 9 are almost twice as susceptible to breaks, while chromosomes 1 and 2 are almost twice as susceptible to gaps, as would be expected based on a random distribution of damage among chromosomes.
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