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Updated: Jul 30, 2026

Detection of In Situ Protein-protein Complexes at the Drosophila Larval Neuromuscular Junction Using Proximity Ligation Assay
Published on: January 20, 2015
A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched
Y Nakano1, I Guerrero, A Hidalgo
1ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK.
Abstract:
The patterning of cells in insect segments requires the exchange of information between cells, which in Drosophila depends on the activity of members of the segment-polarity class of genes. Here we report the molecular characterization of one such gene, patched. We find that patched encodes a large protein with several possible membrane-spanning domains and is expressed in a complex pattern during embryogenesis.
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