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Updated: Mar 10, 2026

Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers
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"Hot-wire" microfluidic flowmeter based on a microfiber coupler.

Shao-Cheng Yan, Zeng-Yong Liu, Cheng Li

    Optics Letters
    |December 16, 2016
    PubMed
    Summary

    We developed a novel microfluidic flowmeter using an optical microfiber coupler (MC) for precise liquid flow measurement. This device achieves ultrahigh sensitivity, enabling detection of minute flow rate changes.

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    Area of Science:

    • Optoelectronics
    • Microfluidics
    • Sensor Technology

    Background:

    • Optical microfiber couplers (MC) enable light-liquid interactions.
    • Microfluidic platforms require efficient methods for sensing and measurement.
    • Direct light-liquid interaction is challenging due to coupling issues.

    Purpose of the Study:

    • To present a microfluidic platform for strong light-liquid interaction.
    • To demonstrate a microfluidic flowmeter with high sensitivity.
    • To overcome input/output coupling conflicts in integrated devices.

    Main Methods:

    • Wrapping a functionalized optical microfiber coupler (MC) around a capillary.
    • Developing a gold-integrated helical MC device for a "hot-wire" flowmeter.
    • Utilizing the cooling effect of microfluid flow on the MC to shift resonant wavelength.

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    Main Results:

    • Achieved strong direct and indirect light-liquid interaction.
    • Demonstrated a microfluidic flowmeter with ultrahigh flow rate sensitivity of 2.183 nm/(μl/s) at 1 μl/s.
    • Attained a minimum detectable flow rate change of 9 nl/s at 1 μl/s.

    Conclusions:

    • The proposed platform enables seamless light-liquid interaction for sensing applications.
    • The "hot-wire" microfluidic flowmeter offers unprecedented sensitivity and detection limits.
    • This approach provides a robust solution for precise microfluidic flow monitoring.