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Glucose-6-phosphate dehydrogenase deficiency (G6PD) as a risk factor of male neonatal sepsis

Z Rostami-Far1, K Ghadiri2, M Rostami-Far3

  • 1Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran.

Journal of Medicine and Life
|December 16, 2016
PubMed

Insights

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is more common in neonates with sepsis, suggesting it

Area of Science:

  • Pediatrics
  • Neonatology
  • Genetics

Background:

  • Neonatal sepsis affects male infants more frequently, with unknown causes.
  • Glucose-6-phosphate dehydrogenase (G6PD) is crucial for white blood cell (WBC) function in fighting infections.
  • NADPH, produced via the pentose phosphate pathway involving G6PD, is essential for WBCs' antimicrobial respiratory burst.

Purpose of the Study:

  • To investigate the prevalence of G6PD deficiency in neonates diagnosed with sepsis.
  • To explore the association between G6PD deficiency and neonatal sepsis risk.

Main Methods:

  • A comparative study involving 76 neonates with sepsis and 1214 healthy neonates.
  • G6PD deficiency was identified using the fluorescent spot test.
  • White blood cell counts and neutrophil percentages were analyzed in relation to G6PD status.

Main Results:

  • The prevalence of G6PD deficiency was significantly higher in the sepsis group compared to the control group (p=0.03).
  • While WBC counts and neutrophil percentages were lower in G6PD deficient neonates, the differences were not statistically significant (p=0.77 and p=0.86, respectively).

Conclusions:

  • G6PD deficiency emerges as a significant risk factor for developing neonatal sepsis.
  • The findings support G6PD deficiency as a potential explanation for the higher incidence of sepsis in male infants.
  • Routine newborn screening for G6PD deficiency is recommended to identify at-risk infants.

Keywords:
glucose-6-phosphate dehydrogenaserisk factorsepsis

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