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Related Concept Videos

Changes in the Appendicular Skeleton with Age01:09

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Knee Joint01:23

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The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Updated: Mar 10, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
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[Joint replacement in the elderly].

C Baier1, J Grifka2, A Keshmiri2

  • 1Orthopädische Klinik für die Universität Regensburg, Asklepios Klinikum Bad Abbach, Kaiser-Karl V.-Allee 3, 93077, Bad Abbach, Deutschland. dr.clemensbaier@gmail.com.

Der Orthopade
|December 16, 2016
PubMed
Summary
This summary is machine-generated.

Total hip or knee replacement in elderly patients requires individualized care. Prioritizing stability and pain-free mobility is crucial for successful outcomes in older adults undergoing arthroplasty.

Keywords:
GeriatricsPain-free mobilityStabilityTotal joint arthroplastyTraumatology

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Area of Science:

  • Orthopedic Surgery
  • Geriatric Medicine

Background:

  • Elderly patients present unique challenges for joint replacement surgery compared to younger individuals.
  • Factors like chronological vs. biological age, activity levels, and patient expectations necessitate tailored treatment approaches.

Purpose of the Study:

  • To highlight the special considerations for replacement arthroplasty in the elderly population.
  • To emphasize the importance of individualizing patient therapy based on specific geriatric factors.

Main Methods:

  • Review of indications, preoperative preparation, postoperative care, implant selection, and intraoperative techniques for elderly patients.
  • Analysis of clinical results in elderly cohorts undergoing arthroplasty.

Main Results:

  • Significant differences exist in indications, surgical techniques, and outcomes for elderly patients compared to younger counterparts.
  • Implant selection and surgical approach must account for patient-specific factors and implant characteristics.

Conclusions:

  • Individualized therapy is paramount in elderly patients undergoing joint replacement.
  • Priority should be given to achieving stability and pain-free mobility in the elderly for optimal functional recovery.