Tau Oligomers as Pathogenic Seeds: Preparation and Propagation In Vitro and In Vivo
Related Experiment Video
Updated: Mar 10, 2026

Inoculation Strategies to Infect Plant Roots with Soil-Borne Microorganisms
Published on: March 1, 2022
Julia E Gerson1,2, Urmi Sengupta1,2, Rakez Kayed3,4,5
1George P. and Cynthia Woods Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Abstract:
Tau oligomers have been shown to be the main toxic tau species in a number of neurodegenerative disorders. In order to study tau oligomers both in vitro and in vivo, we have established methods for the reliable preparation, isolation, and detection of tau oligomers. Methods for the seeding of tau oligomers, isolation of tau oligomers from tissue, and detection of tau oligomers using tau oligomer-specific antibodies by biochemical and immunohistochemical methods are detailed below.
Related Concept Videos
Plant Tissue Culture
Transgenic Plants
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...

