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Thromboembolic events in patients with inflammatory bowel disease

Farjah H Algahtani1, Youssef M K Farag2, Abdulrahman M Aljebreen3

  • 1Department of Medicine, Division of Hematology/Oncology, King Saud University College of Medicine and King Khalid University Hospital, Riyadh, Saudi Arabia.

Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
|December 16, 2016
PubMed

Insights

In patients with inflammatory bowel disease (IBD), a family history of thrombosis is a significant predictor of developing blood clots. This finding is crucial for risk assessment in IBD patients, especially in populations with high consanguinity.

Area of Science:

  • Gastroenterology
  • Hematology
  • Genetics

Background:

  • Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is linked to coagulation abnormalities and a hyper-coagulable state.
  • Understanding risk factors for thromboembolic events in IBD is critical, particularly in populations with high consanguinity.

Purpose of the Study:

  • To investigate the risk factors associated with thromboembolic events in patients diagnosed with inflammatory bowel disease (IBD).
  • To assess the prevalence of thrombosis in a Saudi IBD population with a high rate of consanguinity.

Main Methods:

  • A prospective cohort study involving 100 Saudi patients with IBD (72% Crohn's disease, 28% ulcerative colitis) was conducted over one year.
  • Data collection utilized specifically designed case report forms (CRFs) by trained research personnel.
  • Statistical analysis adjusted for age and gender to identify significant predictors of thrombosis.

Main Results:

  • Eight percent (8%) of IBD patients experienced at least one thrombotic event, including deep venous thrombosis (DVT) and pulmonary embolism (PE).
  • A family history of deep venous thrombosis was present in 5% of patients, and a family history of pulmonary embolism in 4%.
  • A family history of any thrombotic event was the sole statistically significant predictor of thrombosis in IBD patients (Risk Ratio = 9.22).

Conclusions:

  • Thromboembolic events occurred in 8% of IBD patients within a high consanguinity population.
  • A positive family history of pulmonary embolism emerged as a predictor of thrombosis.
  • Further research is warranted to elucidate the role of genetic factors in IBD-associated thrombosis within this demographic.
Abstract

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