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Related Experiment Video

Updated: Mar 10, 2026

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

HIV Latency TORn Down.

¹Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy; Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy.

Cell Host & Microbe

|December 16, 2016

Summary

This summary is machine-generated.

Scientists found that the mTOR kinase is key to reactivating the human immunodeficiency virus (HIV) from its latent state. This discovery could lead to new strategies for eliminating the persistent HIV reservoir in infected individuals.

Keywords:

HIV latency mTOR therapy

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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Area of Science:

Virology
Immunology
Molecular Biology

Background:

Combination antiretroviral therapy (cART) effectively controls human immunodeficiency virus (HIV) replication.
cART fails to eradicate HIV due to a persistent viral reservoir of latently infected cells.
Latent HIV DNA within these reservoirs poses a significant barrier to achieving a functional cure.

Purpose of the Study:

To investigate molecular mechanisms that control the reactivation of latent HIV.
To identify potential therapeutic targets for purging the latent HIV reservoir.

Main Methods:

Utilized cell culture models of latent HIV infection.
Employed genetic and pharmacological inhibition of the mTOR kinase pathway.
Assessed HIV reactivation using molecular assays.

Main Results:

The mechanistic target of rapamycin (mTOR) kinase signaling pathway was found to be essential for HIV reactivation from latency.
Inhibition of mTOR activity suppressed HIV reactivation in cellular models.
Targeting mTOR represents a potential strategy to control or eliminate latent HIV.

Conclusions:

mTOR kinase plays a critical role in the reactivation of latent HIV.
Modulating mTOR signaling may offer a novel approach to target the latent HIV reservoir.
Further research into mTOR inhibitors could advance HIV cure strategies.