Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

4.5K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.5K
Protein Networks02:26

Protein Networks

4.6K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K
Structural Protein Function01:56

Structural Protein Function

30.3K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.3K
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

2.8K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.8K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

10.9K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.9K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

57
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
57

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ERG orchestrates a dedifferentiation-senescence-inflammation triad in prostate cancer.

Molecular cancer research : MCR·2026
Same author

Targeting arginine metabolism overcomes chemotherapy resistance in aggressive-variant prostate cancers.

iScience·2026
Same author

Quantitative prediction of oil-water interfacial tension in surfactant systems using dissipative particle dynamics.

Soft matter·2026
Same author

Assessment and Optimization of Force Fields for Glycine Polymorphism and Solution Properties.

Journal of chemical theory and computation·2026
Same author

Targeting Wnt/β-catenin and circadian regulator restores PRC2/EZH2-controlled chromatin bivalency and suppresses cell state diversity.

The Journal of clinical investigation·2026
Same author

Clusterin reverses epitheliopathy, reduces inflammation, and restores goblet cells and corneal nerves in a mouse model of autoimmune dry eye.

Scientific reports·2026

Related Experiment Video

Updated: Mar 10, 2026

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay
06:51

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay

Published on: July 21, 2021

3.3K

Clusterin as a therapeutic target.

Mark R Wilson1, Amina Zoubeidi2

  • 1a School of Biological Sciences , University of Wollongong , Wollongong , Australia.

Expert Opinion on Therapeutic Targets
|December 17, 2016
PubMed
Summary
This summary is machine-generated.

Clusterin (CLU), a protein implicated in Alzheimer disease and cancer, presents therapeutic challenges due to its complex structure. Gene-level inhibition using antisense approaches offers a promising strategy to target CLU

Keywords:
Alzheimer diseaseClusterinapoptosiscancerchaperoneclearancedry eyeprotein aggregationprotein folding

More Related Videos

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

7.5K
Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions
11:57

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Published on: April 21, 2016

7.1K

Related Experiment Videos

Last Updated: Mar 10, 2026

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay
06:51

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay

Published on: July 21, 2021

3.3K
Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
08:21

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery

Published on: June 28, 2019

7.5K
Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions
11:57

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Published on: April 21, 2016

7.1K

Area of Science:

  • Molecular Biology
  • Oncology
  • Neuroscience

Background:

  • Clusterin (CLU) is a stress-activated molecular chaperone involved in proteostasis and cell survival.
  • CLU is upregulated in Alzheimer disease and therapy-resistant cancers, making it a potential therapeutic target.
  • The complex structure of CLU hinders small molecule inhibitor development, favoring gene-expression targeting.

Purpose of the Study:

  • Review recent advances in understanding CLU's role in proteostasis, cellular trafficking, and disease.
  • Evaluate CLU as a therapeutic target in oncogenesis.
  • Summarize the current status of CLU antisense inhibitor OGX011 in pre-clinical and clinical studies.

Main Methods:

  • Literature review of recent advances in CLU research.
  • Analysis of CLU's involvement in disease pathways, particularly cancer.
  • Assessment of pre-clinical and clinical data for CLU antisense inhibitor OGX011.

Main Results:

  • CLU plays significant roles in protein homeostasis, cell death inhibition, and pro-survival signaling.
  • CLU is implicated in the progression of Alzheimer disease and various cancers.
  • Antisense inhibition of CLU expression is a viable strategy, with OGX011 showing promise.

Conclusions:

  • CLU is a validated therapeutic target in cancer, particularly in light of its role in oncogenesis.
  • Antisense inhibition represents a promising strategy for targeting CLU, despite challenges.
  • Further research and careful consideration of therapeutic windows and potential side effects are crucial for CLU-targeted therapies.