[In vitro antifungal spectrum of ciclopiroxolamine]

The ciclopiroxolamine is a new synthetic antifungal agent related to pyridones; it is the ethanolamine salt of the pyridone acid 6-cyclohexyl 1-hydroxy 4-methyl 2 (1H). The antifungal properties of this molecule was tested in vitro against pathogenic species such as yeasts. (Candida, Torulopsis, Malassezia), moulds (Aspergillus, Scopulariopsis) and dermatophytes, (Microsporum, Trichophyton, Epidermophyton) using an agar dilution method (Sabouraud or Dixon). The results seem to be remarkably homogeneous whatever the strain tested. The MIC obtained with moulds (less sensitive) range between 10-20 micrograms/ml. Whereas they range between 1 and 10 micrograms/ml with yeasts and dermatophytes. On account of the lack of in vivo toxicity of ciclopiroxolamine and of the level of concentrations used in dermatology (1% ointment), the ciclopiroxolamine has a particularly interesting broad spectrum on fungi which induce cutaneous mycoses.