[Comparative study of 2 antibiotic prophylaxis regimens in endoscopic prostatic surgery]

Area of Science:

• Urology
• Infectious Diseases
• Surgical Prophylaxis

Background:

• Antibiotic prophylaxis is crucial in preventing infections following transurethral prostate resection.
• Optimizing antibiotic regimens aims to balance efficacy with reduced side effects and costs.

Purpose of the Study:

• To compare the efficacy and safety of a 24-hour antibiotic prophylaxis regimen versus a single-dose cefamandole injection for patients undergoing endoscopic prostate resection.

Main Methods:

• A randomized controlled trial involving 122 patients undergoing endoscopic prostate resection.
• Patients were divided into two groups: one receiving 24-hour cefamandole prophylaxis and the other a single cefamandole injection at anesthesia induction.
• Infection rates (obvious and occult) and causative pathogens, primarily Pseudomonas aeruginosa, were monitored.

Main Results:

• Both treatment groups exhibited comparable outcomes regarding patient demographics, surgical parameters, and recovery milestones.
• The 24-hour prophylaxis group had 8 obvious and 10 occult infections, while the single-injection group had 11 obvious and 4 occult infections.
• No statistically significant difference in infection rates was observed between the two groups.

Conclusions:

• A single cefamandole injection is as effective as a 24-hour regimen in preventing infections after endoscopic prostate resection.
• The single-injection method is preferred due to its lower cost and comparable safety profile.