[Changes in thymocyte DNA template activity under the effect of agents acting on the central nervous system]

The authors studied the effect of phrenolon, amitriptyline, piracetam, caffeine (concentrations of 10(-7), 10(-6), 10(-5) M), analgin, and amidopyrine (concentrations of 2.5 10(-7), 2.5 10(-6), 2.5 10(-5) M) on the matrix activity of thymocyte DNA. The thymocyte suspension was derived from the thymus of adrenalectomized male rats. The matrix activity of the thymocyte DNA was evaluated according to the ability of these cells to reduce the incorporation of 3H-uridine into thymocyte mRNA. Biosynthesis of thymocyte mRNA reduced under the effect of phrenolon, amitriptyline, and analgin. When phrenolon, amitriptyline, analgin, and amidopyrine were administered together with triamcinolone acetonide, the inhibiting effect of the latter agent on the matrix activity of thymocyte DNA increased; piracetam and caffeine failed to produce such an effect. The practical significance of the obtained results in the clinic or emergencies is discussed.