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Related Concept Videos

Patch Clamp01:18

Patch Clamp

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Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
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Pediatric patch testing: A 10-year retrospective study.

Mona Ascha1, Mahwish Irfan2, James Bena3

  • 1Case Western Reserve University School of Medicine, Cleveland, Ohio.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|December 17, 2016
PubMed
Summary
This summary is machine-generated.

Patch testing is crucial for diagnosing allergic contact dermatitis in children. This review identified nickel and cobalt as common allergens, with many patients experiencing improvement after positive test results.

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Area of Science:

  • Dermatology
  • Pediatric Allergy

Background:

  • Patch testing is the gold standard for diagnosing allergic contact dermatitis (ACD).
  • Pediatric ACD diagnosis and management require specific considerations.

Purpose of the Study:

  • To conduct a 10-year retrospective review of pediatric patch testing.
  • To identify common allergens and outcomes in children diagnosed with ACD.

Main Methods:

  • Retrospective analysis of 157 patients (≤18 years) undergoing patch testing (2005-2015).
  • Testing followed North American Contact Dermatitis Group standards.
  • Positive reaction defined as 1+ or greater allergen reaction with avoidance information.

Main Results:

  • Nickel and cobalt were the most frequent allergens identified.
  • Males showed higher positive reactions to fragrance mix 1.
  • Patients with atopy history were more likely to react to cobalt and chromium.
  • 38.2% of patients had follow-up, with 60.7% reporting improvement.

Conclusions:

  • Pediatric patch testing provides valuable data on common allergens, improving patient care.
  • Awareness of patch testing can be an alternative to systemic immunosuppressants for primary care practitioners.