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Atopy patch test in children with atopic dermatitis.

Nualanong Visitsunthorn¹, Sunsanee Chatpornvorarux¹, Punchama Pacharn¹

¹Division of Allergy and Immunology, Faculty of Medicine, Department of Pediatrics, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

|December 17, 2016

Summary

This summary is machine-generated.

Atopy patch tests (APTs) and skin prick tests (SPTs) show high specificity for diagnosing food allergies in children with atopic dermatitis. While APTs demonstrated good specificity, both tests had low sensitivity for identifying allergies.

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Area of Science:

Allergy and Immunology
Pediatric Dermatology
Diagnostic Testing

Background:

Atopic dermatitis frequently co-occurs with food and aeroallergen sensitivities.
Accurate diagnosis of these allergies is crucial for effective management.

Purpose of the Study:

To evaluate the efficacy of atopy patch tests (APTs) and skin prick tests (SPTs) in diagnosing allergies in children with atopic dermatitis.
Comparison of APTs and SPTs using locally sourced allergen extracts.

Main Methods:

Prospective, self-controlled study involving 56 children diagnosed with atopic dermatitis.
APTs, SPTs, and oral food challenges were conducted.
Allergen extracts included common foods and environmental allergens.

Main Results:

APTs showed 49% positivity for food allergens, while SPTs showed 54.7% positivity.
APTs demonstrated high specificity (90.2%) and moderate positive predictive value (65.2%) for food allergies.
SPTs also exhibited high specificity (93.9%) with a higher positive predictive value (75%) for food allergies.
Both tests showed low sensitivity for food allergies (40% for both).
Reactivity to environmental allergens varied between APTs and SPTs.

Conclusions:

Atopy patch tests using locally prepared lyophilized allergen extracts are safe for evaluating suspected food allergies in children with atopic dermatitis.
APTs offer high specificity and a good positive predictive value but exhibit low sensitivity.
SPTs also show high specificity and a better positive predictive value for food allergies in this population.