Synthesis, antibacterial and antimutagenic activity of zerumbone-bicarbonyl analogues
S C Santosh Kumar1, P S Negi2, J R Manjunatha1
1Spice and Flavour Science Department, CSIR-Central Food Technological Research Institute, Mysuru 570 020, India.
Abstract:
Synthesis of new zerumbone-bicarbonyl analogues by SeO2 oxidation is reported. Selective oxidation of methyl at C-13 to an aldehyde and a ketone with exo-cyclic double bond between C-13 and C-6 in zerumbone has been recognized. Both these compounds have an additional conjugated-carbonyl-functionality. They exhibited significantly higher antimutagenic activity than zerumbone against Salmonella tester strains. They are more active against Gram positive bacteria than Gram negative bacteria; however zerumbone showed highest activity against E. coli, whereas its derivatives were least effective against E. coli.
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