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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Related Experiment Video

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Generation of Induced Pluripotent Stem Cells by Reprogramming Human Fibroblasts with the Stemgent Human TF Lentivirus Set
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Induced pluripotent stem cell technology: a decade of progress.

Yanhong Shi1, Haruhisa Inoue2, Joseph C Wu3

  • 1Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, California 91010, USA.

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Induced pluripotent stem cell (iPSC) technology has revolutionized regenerative medicine and drug discovery. Advances in iPSC applications, combined with gene editing and organoids, offer powerful platforms for precision medicine.

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Area of Science:

  • Stem Cell Biology
  • Regenerative Medicine
  • Drug Discovery

Background:

  • Induced pluripotent stem cell (iPSC) technology, pioneered a decade ago, has significantly advanced stem cell research.
  • Human iPSCs are crucial tools for disease modeling, pharmaceutical development, and therapeutic strategies.

Observation:

  • Novel insights into pathological mechanisms have been uncovered through iPSC applications.
  • New therapeutic compounds identified via iPSC screening are progressing towards clinical use.
  • The first human clinical trial utilizing iPSC-derived products has commenced.

Findings:

  • The integration of iPSC technology with gene editing and 3D organoid development enhances platform capabilities.
  • iPSC-based approaches are increasingly powerful for disease modeling and drug discovery.
  • Significant progress has been made in cell therapy development using iPSC-derived products.

Implications:

  • iPSC technology is pivotal for advancing precision medicine and personalized therapeutic strategies.
  • The synergy between iPSCs, gene editing, and organoids amplifies their potential in regenerative medicine.
  • Continued research and development in iPSC applications promise future breakthroughs in treating complex diseases.