Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

1.3K
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.3K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

4.6K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.6K
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

7.9K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
7.9K
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

7.0K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
7.0K
Antihypertensive Drugs: Action of β1 Blockers01:17

Antihypertensive Drugs: Action of β1 Blockers

2.2K
β1-receptors are primarily located in the heart and kidneys. In cardiac myocytes, these receptors interact with neurotransmitters released by the sympathetic nervous system during heightened activity or danger. As a result, β1-receptors get activated, initiating a series of biochemical processes. Excessive activation of beta receptors due to chronic stress can abnormally increase heart rate and contractility, resulting in high blood pressure or hypertension. To counteract this,...
2.2K
Blood Pressure01:30

Blood Pressure

5.4K
Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Granular soil densification using expansive resins.

Scientific reports·2026
Same author

The evolution of therapy for chronic osteoarthritic knee pain: Feasibility, safety and clinical outcomes of transpedal access for genicular artery embolization.

European journal of radiology·2026
Same author

Risk of thrombosis with thrombocytopaenia syndrome (TTS) after vaccination with AZD1222: a European VAC4EU post-authorisation safety study.

Vaccine·2026
Same author

Optometrist attitudes towards delivering intravitreal injections in Aotearoa New Zealand.

Clinical & experimental optometry·2026
Same author

Microbiome education at under-resourced institutions: current status, barriers, and approaches to successful implementation.

Journal of microbiology & biology education·2026
Same author

Trajectory of weight regain after cessation of GLP-1 receptor agonists: a systematic review and nonlinear meta-regression.

EClinicalMedicine·2026

Related Experiment Video

Updated: Mar 10, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography
07:25

Assessing Murine Resistance Artery Function Using Pressure Myography

Published on: June 7, 2013

23.3K

Novel Pathophysiological Mechanisms in Hypertension.

Rohan Samson1, Andrew Lee2, Sean Lawless2

  • 1Tulane University Heart and Vascular Institute, Tulane School of Medicine, 1430 Tulane Avenue, SL-48, New Orleans, LA, 70112, USA. rsamson@tulane.edu.

Advances in Experimental Medicine and Biology
|December 17, 2016
PubMed
Summary

Hypertension, a common disease, poses significant risks. Understanding novel mechanisms like immunity and inflammation is crucial for better blood pressure control and reduced cardiovascular events.

Keywords:
ADMAAT2 receptorAngiotensin- (1–7)Bone marrowHypertensionImmune systemMineralocorticoid receptorNeuro-inflammationPathophysiologyRAASVEGF

More Related Videos

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

5.7K
Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.3K

Related Experiment Videos

Last Updated: Mar 10, 2026

Assessing Murine Resistance Artery Function Using Pressure Myography
07:25

Assessing Murine Resistance Artery Function Using Pressure Myography

Published on: June 7, 2013

23.3K
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

5.7K
Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.3K

Area of Science:

  • Cardiology
  • Nephrology
  • Immunology

Background:

  • Hypertension is a prevalent human disease with substantial cardiovascular and renal risks.
  • Despite extensive research, the precise cause of hypertension in individual patients often remains unknown.
  • Aggressive blood pressure management, as shown in the SPRINT trial, is vital for reducing morbidity and mortality.

Purpose of the Study:

  • To review novel pathophysiological mechanisms contributing to hypertension.
  • To explore the roles of immunity, inflammation, and vascular endothelial homeostasis in hypertension.
  • To discuss potential therapeutic strategies based on these emerging mechanisms.

Main Methods:

  • Literature review of recent research on hypertension pathophysiology.
  • Focus on the interplay between the immune system, inflammatory processes, and vascular endothelium.
  • Analysis of therapeutic implications derived from novel pathophysiological insights.

Main Results:

  • Emerging evidence highlights the significant role of immune and inflammatory pathways in hypertension development.
  • Vascular endothelial dysfunction is increasingly recognized as a key factor in blood pressure dysregulation.
  • These novel mechanisms offer potential targets for future antihypertensive therapies.

Conclusions:

  • Understanding the intricate roles of immunity and inflammation is essential for advancing hypertension treatment.
  • Targeting vascular endothelial homeostasis may provide new avenues for managing resistant hypertension.
  • Mechanism-based therapeutic strategies are needed to improve outcomes for patients failing to reach blood pressure goals.