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Nickel-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms
Tian Qin1, Lara R Malins1, Jacob T Edwards1
1The Scripps Research Institute (TSRI), North Torrey Pines Road, La Jolla, CA, 92037, USA.
Abstract:
Two named reactions of fundamental importance and paramount utility in organic synthesis have been reinvestigated, the Barton decarboxylation and Giese radical conjugate addition. N-hydroxyphthalimide (NHPI) based redox-active esters were found to be convenient starting materials for simple, thermal, Ni-catalyzed radical formation and subsequent trapping with either a hydrogen atom source (PhSiH3 ) or an electron-deficient olefin. These reactions feature operational simplicity, inexpensive reagents, and enhanced scope as evidenced by examples in the realm of peptide chemistry.
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