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Assisted reproductive technology and severe postpartum haemorrhage: a case-control study.
L T Nyfløt1,2, I Sandven3, N B Oldereid4
1Division of Gynaecology and Obstetrics, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Women using assisted reproductive technology face a higher risk of severe postpartum hemorrhage. This risk is significantly elevated in multiple pregnancies, underscoring the importance of single embryo transfer.
Area of Science:
- Obstetrics and Gynecology
- Reproductive Medicine
- Maternal Health
Background:
- Assisted reproductive technology (ART) is increasingly used for conception.
- The association between ART and severe postpartum hemorrhage (PPH) requires further investigation.
Purpose of the Study:
- To investigate the association between assisted reproductive technology and severe postpartum hemorrhage (PPH).
Main Methods:
- A case-control study was conducted in Norway.
- The study included 1064 cases of severe PPH and 2059 controls.
- Multivariable logistic regression was used for analysis.
Main Results:
- ART was associated with an increased risk of severe PPH (crude OR = 2.92).
- Confounding effects were observed for mode of delivery and anticoagulant medication.
- An increased risk of severe PPH was noted in both multiple pregnancies (adjusted OR = 7.00) and single gestations (adjusted OR = 1.58) among ART users.
Conclusions:
- Women conceiving via ART have an elevated risk of severe PPH.
- The high risk in multiple ART pregnancies supports single embryo transfer to mitigate PPH risk.
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