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Published on: September 25, 2016
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Intracardiac thrombus in Behçet's disease
I Ben Ghorbel1, N Belfeki, M H Houman
1Department of Internal Medicine, University Hospital of La Rabta, Tunis. benghorbelimed@gmail.com.
Reumatismo
|December 17, 2016
Summary
Intracardiac thrombus (ICT) is a rare complication of Behçet's disease (BD). This study found that ICT in BD patients often presents with respiratory symptoms and can involve other cardiovascular issues, responding to combined immunosuppressive therapy.
Area of Science:
- Cardiology
- Rheumatology
- Internal Medicine
Background:
- Behçet's disease (BD) is a multisystem inflammatory disorder.
- Intracardiac thrombus (ICT) is an uncommon but significant complication of BD.
- This study investigates the clinical characteristics and management of ICT in BD patients.
Observation:
- Eight male patients with BD were diagnosed with ICT, with a mean age of 30.8 years.
- Common presenting symptoms included hemoptysis, chest pain, and dyspnea.
- Associated conditions included pulmonary artery aneurysm, vena cava thrombosis, pulmonary embolism, and deep vein thrombosis.
Findings:
- Echocardiography was sufficient for ICT diagnosis.
- Chest CT identified pulmonary vasculo-Behçet lesions in 4 cases.
- Five out of eight patients achieved clinical remission and ICT resolution with treatment.
Implications:
- Combined immunosuppressive therapy, particularly prednisone and cyclophosphamide, may be crucial for managing ICT in BD.
- Early diagnosis and comprehensive treatment are essential for improving outcomes in BD patients with ICT.
- Further research is warranted to elucidate the pathogenesis and optimize treatment strategies for ICT in BD.
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