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Updated: Mar 10, 2026

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
Published on: August 11, 2023
Hot Topics in Pharmacotherapy for Neovascular Age-Related Macular Degeneration
Khalil Ghasemi Falavarjani1, Srinivas R Sadda2
1Doheny Eye Institute, 1355 San Pablo Street, DVRC 211, Los Angeles, CA 90033, United States.
Background:
The preferred approach for the treatment of neovascular age-related macular degeneration (AMD) is frequent intravitreal injections of the anti-vascular endothelial growth factor (VEGF) agents. However, considering the limitations of current anti-VEGF approaches, including the need for frequent injections, inadequate response in some patients, and a relatively short duration of effect, several new therapeutic modalities are under evaluation.
Methods:
A comprehensive review of the literature was performed on the new treatment modalities for neovascular AMD, and the relevant studies were discussed.
Results:
The treatment modalities for neovascular AMD include new anti-VEGF drugs, new drug delivery systems and new targets in the pathogenic cascade of choroidal neovascularization. These new modalities are in different phases of clinical development.
Conclusion:
The results of the completed studies reporting the new therapeutic modalities for neovascular AMD thus far are promising.
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