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Tumor Regression Patterns in Retinoblastoma.

Saemah Nuzhat Zafar1, Sorath Noorani Siddiqui1, Naima Zaheer1

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Tumor regression patterns in retinoblastoma vary by International Classification of Retinoblastoma (ICRB) group. Type IV regression was most common overall, but specific patterns differed across ICRB groups A, B, C, and D.

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Area of Science:

  • Ophthalmology
  • Pediatric Oncology
  • Medical Imaging

Background:

  • Retinoblastoma is the most common intraocular malignancy in children.
  • Understanding tumor regression patterns is crucial for assessing treatment efficacy.

Purpose of the Study:

  • To observe and categorize tumor regression types following treatment in retinoblastoma patients.
  • To identify common regression patterns associated with different International Classification of Retinoblastoma (ICRB) groupings.

Main Methods:

  • A descriptive study was conducted on children with retinoblastoma.
  • Tumor regression was assessed via dilated fundus examination under anesthesia after chemotherapy cycles.
  • Regression patterns were documented using RetCam II imaging.

Main Results:

  • Seventy-four retinoblastoma tumors were analyzed across ICRB groups A, B, C, and D.
  • Type IV regression was the most frequent overall (39.1%), followed by Type II (29.7%), Type III (25.6%), and Type I (5.4%).
  • Specific regression patterns varied by ICRB group, with Type IV predominant in Group A (100%) and Group B (39.5%), and Types II and IV observed in Group C, and Type II in Group D.

Conclusions:

  • Treatment response, indicated by regression patterns, is dependent on the ICRB group of the retinoblastoma.
  • The findings highlight the importance of ICRB staging in predicting and evaluating treatment outcomes for retinoblastoma.