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Published on: August 4, 2011
Tumor Regression Patterns in Retinoblastoma
Saemah Nuzhat Zafar1, Sorath Noorani Siddiqui1, Naima Zaheer1
1Department of Pediatric Ophthalmology, Al-Shifa Trust Eye Hospital, Rawalpindi.
Insights
Tumor regression patterns in retinoblastoma vary by International Classification of Retinoblastoma (ICRB) group. Type IV regression was most common overall, but specific patterns differed across ICRB groups A, B, C, and D.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Medical Imaging
Background:
- Retinoblastoma is the most common intraocular malignancy in children.
- Understanding tumor regression patterns is crucial for assessing treatment efficacy.
Purpose of the Study:
- To observe and categorize tumor regression types following treatment in retinoblastoma patients.
- To identify common regression patterns associated with different International Classification of Retinoblastoma (ICRB) groupings.
Main Methods:
- A descriptive study was conducted on children with retinoblastoma.
- Tumor regression was assessed via dilated fundus examination under anesthesia after chemotherapy cycles.
- Regression patterns were documented using RetCam II imaging.
Main Results:
- Seventy-four retinoblastoma tumors were analyzed across ICRB groups A, B, C, and D.
- Type IV regression was the most frequent overall (39.1%), followed by Type II (29.7%), Type III (25.6%), and Type I (5.4%).
- Specific regression patterns varied by ICRB group, with Type IV predominant in Group A (100%) and Group B (39.5%), and Types II and IV observed in Group C, and Type II in Group D.
Conclusions:
- Treatment response, indicated by regression patterns, is dependent on the ICRB group of the retinoblastoma.
- The findings highlight the importance of ICRB staging in predicting and evaluating treatment outcomes for retinoblastoma.
Objective:
To observe the types of tumor regression after treatment, and identify the common pattern of regression in our patients.
Study Design:
Descriptive study.
Place And Duration Of Study:
Department of Pediatric Ophthalmology and Strabismus, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan, from October 2011 to October 2014.
Methodology:
Children with unilateral and bilateral retinoblastoma were included in the study. Patients were referred to Pakistan Institute of Medical Sciences, Islamabad, for chemotherapy. After every cycle of chemotherapy, dilated fundus examination under anesthesia was performed to record response of the treatment. Regression patterns were recorded on RetCam II.
Results:
Seventy-four tumors were included in the study. Out of 74 tumors, 3 were ICRB group A tumors, 43 were ICRB group B tumors, 14 tumors belonged to ICRB group C, and remaining 14 were ICRB group D tumors. Type IV regression was seen in 39.1% (n=29) tumors, type II in 29.7% (n=22), type III in 25.6% (n=19), and type I in 5.4% (n=4). All group A tumors (100%) showed type IV regression. Seventeen (39.5%) group B tumors showed type IV regression. In group C, 5 tumors (35.7%) showed type II regression and 5 tumors (35.7%) showed type IV regression. In group D, 6 tumors (42.9%) regressed to type II non-calcified remnants.
Conclusion:
The response and success of the focal and systemic treatment, as judged by the appearance of different patterns of tumor regression, varies with the ICRB grouping of the tumor.
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