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Related Experiment Videos

Manoela Siqueira Pimenta1, Nayana Santiago Guedis Lobo1, Virna Castelo Vieira1

  • 1Dental School, UNIFOR - University of Fortaleza, Fortaleza, CE, Brazil.

Brazilian Dental Journal
|December 17, 2016
PubMed
Summary

Ocimum gratissimum (Og) mouthwash showed an antiplaque effect in vivo, inhibiting plaque regrowth. However, 0.12% chlorhexidine digluconate (CLX) mouthwash demonstrated superior efficacy compared to Og.

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Area of Science:

  • Oral health research
  • Pharmacology
  • Natural product research

Background:

  • Dental plaque accumulation is a primary factor in oral diseases.
  • Natural compounds are increasingly explored for their therapeutic potential in oral hygiene.
  • Ocimum gratissimum (Og) possesses known antimicrobial properties.

Purpose of the Study:

  • To evaluate the in vivo antiplaque efficacy of Ocimum gratissimum (Og) mouthwash.
  • To compare the antiplaque effect of Og with chlorhexidine digluconate (CLX) and a placebo.
  • To assess the potential of Og as an alternative agent for plaque control.

Main Methods:

  • A 3-day partial-mouth plaque accumulation model was employed.
  • Fifteen healthy volunteers participated in a crossover, double-blind clinical study.

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  • Participants used distilled water (DW), 0.12% chlorhexidine digluconate (CLX), or 10% Og mouthrinses, abstaining from mechanical oral hygiene.
  • Plaque Index (PLI) was recorded on mandibular teeth; Kruskal-Wallis and Mann-Whitney tests were used for analysis.

    • Main Results:

    • A statistically significant difference in plaque inhibition was observed among the groups (p<0.05).
    • Both CLX and Og mouthrinses demonstrated an ability to inhibit plaque regrowth.
    • Chlorhexidine digluconate (CLX) exhibited significantly greater antiplaque efficacy compared to Ocimum gratissimum (Og) (p<0.05).

    Conclusions:

    • Ocimum gratissimum (Og) mouthwash demonstrates a measurable antiplaque effect.
    • While Og shows potential, 0.12% chlorhexidine digluconate remains more effective for plaque inhibition.
    • Further research may explore optimized formulations or combinations of Og for enhanced oral hygiene benefits.