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Updated: Mar 10, 2026

Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene
Published on: March 20, 2017
Csp3 -H Activation without Chelation Assistance in an Iridium Pincer Complex Forming Cyclometallated Products
David A Ahlstrand1, Alexey V Polukeev1, Rocío Marcos2
1Centre for Analysis and Synthesis, Department of Chemistry, Lund University, PO Box 124, 22100, Lund, Sweden.
Abstract:
Cyclometallation of 8-methylquinoline and 2-(dimethylamino)-pyridine in an iridium-based pincer complex is described. The C-H activation of 2-(dimethylamino)pyridine is not chelation assisted, which has not been described before for Csp3 -H bonds in cyclometallation reactions. The mechanism of the cyclometallation of 2-(dimethylamino)pyridine was studied by DFT calculations and kinetic measurements.
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