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Predictive factors for recurrence and clinical outcomes in patients with chronic subdural hematoma
Myung-Hoon Han1, Je Il Ryu1, Choong Hyun Kim1
1Department of Neurosurgery, Hanyang University Guri Hospital, Gyonggi-do, Korea.
Insights
Older patients, obesity, and bilateral surgery increase the risk of chronic subdural hematoma (CSDH) recurrence after bur hole surgery. Understanding these factors is crucial for managing CSDH outcomes.
Area of Science:
- Neurosurgery
- Geriatric Medicine
- Clinical Epidemiology
Background:
- Chronic subdural hematoma (CSDH) is a frequent intracranial hemorrhage in the elderly.
- Previous studies on CSDH recurrence risk factors yield inconsistent results.
Purpose of the Study:
- To identify patient factors associated with CSDH recurrence after bur hole surgery.
- To evaluate the impact of these factors on clinical outcomes.
Main Methods:
- Retrospective analysis of 756 patients undergoing bur hole surgery for CSDH.
- Kaplan-Meier analysis and Cox proportional hazards regression for risk factor identification.
- One-way repeated-measures ANOVA for modified Rankin Scale score assessment.
Main Results:
- A recurrence rate of 13.8% was observed within 6 months post-surgery.
- Independent risk factors for recurrence included age > 75 years, obesity (BMI ≥ 25.0 kg/m²), and bilateral operations.
- Hazard ratios and confidence intervals were calculated for identified risk factors.
Conclusions:
- Age over 75, obesity, and bilateral procedures are significant risk factors for CSDH recurrence post-bur hole surgery.
- These findings highlight key factors influencing CSDH recurrence and patient outcomes.
- Further research is warranted to elucidate the mechanisms underlying these associations.
Abstract:
OBJECTIVE Chronic subdural hematoma (CSDH) is a common type of intracranial hemorrhage in elderly patients. Many studies have suggested various factors that may be associated with the recurrence of CSDH. However, the results are inconsistent. The purpose of this study was to determine the associations among patient factors, recurrence, and clinical outcomes of CSDH after bur hole surgery performed during an 11-year period at twin hospitals. METHODS Kaplan-Meier analysis was performed to evaluate the risk factors for CSDH recurrence. Univariate and multivariate Cox proportional hazards regression analyses were used to calculate hazard ratios with 95% CIs for CSDH recurrence based on many variables. One-way repeated-measures ANOVA was used to assess the differences in the mean modified Rankin Scale score between categories for each risk factor during each admission and at the last follow-up. RESULTS This study was a retrospective analysis of 756 consecutive patients with CSDH who underwent bur hole surgery at the Hanyang University Medical Center (Seoul and Guri) between January 1, 2004, and December 31, 2014. During the 6-month follow-up, 104 patients (13.8%) with recurrence after surgery for CSDH were identified. Independent risk factors for recurrence were as follows: age > 75 years (HR 1.72, 95% CI 1.03-2.88; p = 0.039), obesity (body mass index ≥ 25.0 kg/m2), and a bilateral operation. CONCLUSIONS This study determined the risk factors for recurrence of CSDH and their effects on outcomes. Further studies are needed to account for these observations and to determine their underlying mechanisms.
