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Use of nude mice in experimental neutron capture therapy with 10B-BPA
N Tamaoki1, M Ueda, S Tamauchi
1Department of Pathology, School of Medicine, Tokai University, Kanagawa-ken, Japan.
Pigment Cell Research
|July 1, 1989
Abstract:
Mouse B16 melanoma allografts in nude mice were successfully treated by thermal neutron irradiation after IP injection of 10B-paraboronophenylalanine hydrochloride. The tumor growth was significantly suppressed for 4 weeks after irradiation, compared with animals given neutron irradiation alone. Tumor-bearing nude mice were shown to be useful for evaluating the treatment for melanoma.